General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/BDCA2 and FcER1G Stable
Recombinant CHO-K1 cells stably overexpress human C-type lectin domain family 4 member C (BDCA2) and Fc epsilon receptor Ig (FcER1G) on the surface The surface expression of BDCA2 is validated by FACS analysis
Eurofins Discoverx PathHunter NMU1R Total Internalization U2OS Cell Line, 2 vials. (93-0782C3)
The PathHunter NMU1R Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of nMU1R via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged nMU1R and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the nMU1R receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Salmonella enterica; subsp. enterica; serovar Abony
Salmonella enterica subsp. enterica serovar Abony strain CCM 4518 [NBRC 100797, NCTC 6017, CIP 80.39] is a whole-genome sequenced strain with applications in enteric disease research and zoonotic disease research.
Eurofins Discoverx ChemiScreen Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line, 2 vials. (HTS010C)
The ChemiScreen Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MIP, RANTES) based activation of CCR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR5, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the rhesus macaque version of the protein. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC RD; Rhabdomyosarcoma; Human (Homo sapiens)
Rhabdomyosarcoma (RD) cells are large, multinucleated, spindle-shaped cells isolated from muscle tissue. Use this cell line for your research and for the detection of viruses.
Eurofins Discoverx PathHunter CHO-K1 mCCR7 β-Arrestin Cell Line, 2 vials. (93-0528C2)
The PathHunter mCCR7 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19/MIP-3β) based activation of mCCR7 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCCR7 and EA-tagged β-Arrestin-2. Activation of mCCR7 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Abcam CGP 52432 (mM/ml), GABAB antagonist, 10MM_ML
MW 384.2 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 85 nM). Soluble in 1 ml water to give specified mM/ml concentration.
The product is subject to the following: Abcam Restricted Use Statement
Vector Biolabs Arrestin beta 2 Adenovirus (Ad-Arrestin-2(beta))
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
ACROBiosystems HEK293/Human SORT1 Stable Cell Line
The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
ATCC NIH/3T3; Embryonic Fibroblast; Mouse
NIH/3T3 is a fibroblast cell line that was isolated from a mouse NIH/Swiss embryo. This cell line is highly sensitive to sarcoma virus focus formation and leukemia virus propagation and has proven to be very useful in DNA transfection studies. This cell line is a multiclonal population and we no longer test this cell line for contact inhibition. Please refer to note under specific applications for additional information and new clonal cell line maintaining contact inhibition.
Lonza Walkersville ADSC - Suppl Growth Factors
Stem cells possess the unique ability to proliferate as an undifferentiated cell type then when properly stimulated differentiate into multiple lineages of cells Lonza s ADSC human Adipose Derived Stem Cell Growth BulletKit Medium is a serum containing medium designed to proliferate human adipose derived mesenchymal stem cells (both normal and diseased) in an undifferentiated state The serum used in Lonza s ADSC human Adipose Derived Stem Cell Growth BulletKit Medium is specifically screened to ensure that the serum neither promotes spontaneous differentiation of cells nor inhibits cell differentiation to osteogenic chondrogenic or adipogenic lineages (when properly stimulated with an appropriate differentiation media)
Cell Applications Inc Cryopreserved Colonic Epithelial Cells (HCnEpC), fetal
Cryopreserved Colonic Epithelial Cells (HCnEpC), fetal
Biochain Institute Inc Paraffin Tissue Section Panel - Monkey (Cynomolgus) Normal Tissue, Multi-tissue I, 8 different tissues, 5 slides/PK
BioChain's monkey normal multiple tissue panels are designed for studying tissue specific cellular localization of genes or proteins of interest in different Cynomolgus monkey tissues. Tissues are mounted on positively charged glass slides. Total RNA Northern Blots are available in the identical format, and cDNA from those tissues may also be available for PCR detection.
Eurofins Discoverx ChemiScreen BB3 Bombesin Receptor Stable Cell Line, 2 vials. (HTS160C)
The ChemiScreen BB3 Bombesin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bombesin) based activation of BRS3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses BRS3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of BRS3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.